(+)-L-Tartaric acid bis(dimethylamide)

(+)-L-Tartaric acid bis(dimethylamide) - Names and Identifiers

Name	N,N,N',N'-Tetramethyl-L-tartramide
Synonyms	N,N,N',N'-Tetramethyl-L-tartramide N,N,N',N'-TETRAMETHYL-L-TARTRAMIDE N,N,N',N'-TETRAMETHYL-L-TARTARAMIDE (+)-L-Tartaric acid bis(dimethylamide) (+)-N,N,N',N'-TETRAMETHYL-L-TARTARAMIDE (+)-N,N,N',N'-TETRAMETHYL-L-TARTARDIAMIDE 2,3-dihydroxy-N,N,N',N'-tetramethylbutanediamide (+)-N,N,N',N'-TETRAMETHYL-L-TARTARIC ACID DIAMINE (+)-N,N,N',N'-TETRAMETHYL-L-TARTARIC ACID DIAMIDE (2R,3R)-2,3-Dihydroxy-N,N,N',N'-tetramethylsuccinamide (R,R)-(+)-2,3-DIHYDROXY-N,N,N',N'-TETRAMETHYLSUCCINAMIDE (2R,3R)-2,3-dihydroxy-N,N,N',N'-tetramethylbutanediamide (2R,3S)-2,3-dihydroxy-N,N,N',N'-tetramethylbutanediamide (R,R)-(+)-2,3-Dihydroxy-N,N,N',N'-tetramethylsuccinamide
CAS	26549-65-5
InChI	InChI=1/C8H16N2O4/c1-9(2)7(13)5(11)6(12)8(14)10(3)4/h5-6,11-12H,1-4H3/t5-,6+

(+)-L-Tartaric acid bis(dimethylamide) - Physico-chemical Properties

Molecular Formula	C8H16N2O4
Molar Mass	204.22
Density	1.2441 (rough estimate)
Melting Point	184-186°C(lit.)
Boling Point	342.71°C (rough estimate)
Specific Rotation(α)	46 º (c=3, EtOH)
Flash Point	198.6°C
Solubility	Ethanol (Slightly, Heated), Water (Slightly)
Vapor Presure	3.07E-08mmHg at 25°C
Appearance	Solid
Color	White to Off-White
BRN	1959244
pKa	11.79±0.20(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.4500 (estimate)
MDL	MFCD00025672
Physical and Chemical Properties	alpha:46 o (c=3, EtOH)

(+)-L-Tartaric acid bis(dimethylamide) - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29241990

(+)-L-Tartaric acid bis(dimethylamide) - Introduction

N,N,N',N'-Tetramethyl-L-tartramide is an organic compound with the chemical formula C10H16N2O4. The following is a description of the nature, use, preparation and safety information of N,N,N',N'-Tetramethyl-L-tartramide:

Nature:
1. Appearance: usually white crystalline powder.
2. Solubility: Soluble in water and polar organic solvents, such as Alcohols, Ketones and esters.
3. Melting point and boiling point: melting point of 118-124 degrees Celsius.
4. Molecular weight: 232.25g/mol.

Use:
N,N,N',N'-Tetramethyl-L-tartramide have a wide range of applications in the field of chemistry. They are mainly used as ligands for chiral catalysts and can promote asymmetric catalytic reactions. It can form complexes with transition metals, which can effectively control the stereoselectivity in the synthesis of compounds and help to synthesize chiral molecules. Therefore, N,N,N',N'-Tetramethyl-L-tartramide are often used in organic synthesis to prepare chiral drugs, pesticides, plant protection agents, etc.

Method:
N,N,N',N'-Tetramethyl-L-tartramide can be prepared by reacting methyl L-tartrate with methylamine. First, methyl 1-tartrate is dissolved under acidic conditions, and an excess amount of methylamine is added for reaction. After the reaction, the product N,N,N',N'-Tetramethyl-L-tartramide can be obtained by distillation and purification.

Safety Information:
N,N,N',N'-The use of Tetramethyl-L-tartramide is generally safer. However, as with any chemical, correct experimental procedures should be followed. Care should be taken to avoid contact with strong oxidants and to avoid the production of harmful gases, vapors or fumes. Also, wear appropriate personal protective equipment such as safety glasses and gloves during use. During storage and handling, it should be kept in a dry, low temperature environment, and away from fire and combustible materials. If ingestion or contact with skin, please seek the help of a doctor in time and provide the doctor with relevant chemical information.

Last Update：2024-04-09 21:11:58